Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue.
- Author:
Moon Kyun CHO
1
;
Je Min AN
;
Chul Han KIM
;
Sang Gue KANG
Author Information
- Publication Type:Original Article
- Keywords: Skin; Diabetes mellitus
- MeSH: Aurora Kinase A*; Blotting, Western; Cytokinesis; Diabetes Mellitus; DNA Damage; Humans; Mitosis; Skin*
- From:Archives of Plastic Surgery 2014;41(1):35-39
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Aurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue. METHODS: Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens. RESULTS: Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining. CONCLUSIONS: Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue.
