Relationship between Metabolic Syndrome and Bone Mineral Density in Middle-aged Women.
- Author:
Su Kyung JEON
1
;
Hye Ri HONG
;
Kyong Wook YI
;
Hyun Tae PARK
;
Jung Ho SHIN
;
Nak Woo LEE
;
Tak KIM
;
Hai Joong KIM
;
Jun Young HUR
;
Sun Haeng KIM
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul, Korea. kwyi@korea.ac.kr
- Publication Type:Original Article
- Keywords:
Bone mineral density;
Metabolic syndrome;
Middle-aged women
- MeSH:
Biomarkers;
Body Mass Index;
Bone Density;
Cholesterol;
Female;
Femur Neck;
Glucose;
Humans;
Spine;
Waist Circumference
- From:The Journal of Korean Society of Menopause
2010;16(3):142-147
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: To determine the relationship between metabolic syndrome (MS) and bone mineral density (BMD) in middle-aged women. METHODS: Three hundred eight premenopausal women were included in this study, including 268 women without MS and 40 women confirmed to have MS according to the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria. Clinical markers including anthropometric parameters, the serum lipid profile, and glucose level were determined and analyzed with the BMD at the lumbar spine and femoral neck. RESULTS: There was no significant difference in femoral neck or lumbar BMD between the controls and women with MS. In correlation tests, the body mass index (BMI) showed a significant association with the femoral (r = 0.209, P < 0.001) and lumbar BMD (r = 0.176, P = 0.002). In addition, the waist circumference (WC) was also significantly correlated with the femoral (r = 0.142, P = 0.012) and lumbar BMD (r = 0.113, P = 0.048). CONCLUSION: The BMI and WC showed a significant positive association with the femoral and lumbar spine BMD in premenopausal women. Further studies with a large population will be needed to elucidate the combined effect of MS on BMD in middle-aged women.
