Comparison of Lipid Profile Ratios in Patients with High-grade Brain Cancers according to the Presence of Recurrence during Cancer-related Therapy.
10.7586/jkbns.2017.19.2.107
- Author:
Sanghee KIM
1
Author Information
1. College of Nursing · Research Institute of Nursing Science, Keimyung University, Daegu, Korea. shkim07@gw.kmu.ac.kr
- Publication Type:Original Article
- Keywords:
High-grade Brain Cancers;
Cancer-related Therapy;
Lipid Profile Ratios
- MeSH:
Brain Neoplasms*;
Brain*;
Chemoradiotherapy;
Chemotherapy, Adjuvant;
Cholesterol;
Humans;
Hyperlipidemias;
Lipoproteins;
Prognosis;
Recurrence*;
Triglycerides
- From:Journal of Korean Biological Nursing Science
2017;19(2):107-112
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study was to identify the lipid profile ratios as factors affecting disease progress in patients with high-grade primary brain cancers undergoing concurrent chemoradiotherapy (CCRT) and adjuvant chemotherapy. METHODS: The levels of lipid profile ratios were evaluated by looking at the total cholesterol (TC) to high-density lipoprotein (HDL)-cholesterol (TC/HDL-c), low-density lipoprotein (LDL)-cholesterol to HDL-cholesterol (LDL-c/HDL-c), and triglycerides to HDL-cholesterol (TG/HDL-c). This descriptive research was conducted 7 months after the initiation of CCRT and adjuvant chemotherapy. RESULTS: A total of 36 patients with newly diagnosed primary malignant brain cancer were included in the study. The levels of lipid profile ratios such as TC/HDL-c, LDL-c/HDL-c, TG/HDL-c were significantly different between the patients with and without disease progress at 7 months after initiation of CCRT and adjuvant chemotherapy. CONCLUSION: The lipid profile ratios were indicators affecting disease prognosis with tumor-related factors at 7 months after initiation of CCRT and adjuvant chemotherapy. Therefore, lipid profile ratios indicating hyperlipidemia in patients with high-grade brain cancers should be carefully monitored during and after cancer-related therapy.
