Relationship between Obsessive-Compulsive Disorder and Monoamine Oxidase-A Genetic Polymorphisms in a Korean Population.
- Author:
Min Jung KOH
1
;
Se Joo KIM
;
Chan Hyung KIM
Author Information
1. Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea. spr88@yuhs.ac
- Publication Type:Original Article
- Keywords:
Monoamine oxidase-A;
Polymorphism;
Obsessive-compulsive disorder
- MeSH:
Alleles;
DNA;
Female;
Gene Frequency;
Genetic Variation;
Genotype;
Humans;
Male;
Monoamine Oxidase;
Obsessive Hoarding;
Obsessive-Compulsive Disorder;
Polymorphism, Genetic;
X Chromosome
- From:Korean Journal of Psychopharmacology
2008;19(4):226-232
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: There is increasing evidence that obsessive-compulsive disorder (OCD) is a multidimensional and heterogeneous disorder mediated by a range of different factors, including genetic variation. Our aim was to investigate the possible association of OCD with monoamine oxidase-A (MAO-A) gene polymorphisms in a Korean population. METHODS: Patients with OCD (N=121) and normal individuals (N=276) participated. Genomic DNA was extracted from the peripheral blood of all subjects, and genotypes were determined. Males and females were treated as separate groups because the MAO-A gene is located on the X chromosome. MAO-A genotypes and allele frequencies were compared with the Yale-Brown Obsessive-Compulsive Scale (YBOCS) factor scores of both groups. RESULTS: Male OCD patients exhibited a higher frequency of allele 3.00 and a lower frequency of allele 4.00 than did normal male patients. Additionally, male patients with allele 4.00 scored higher for YBOCS factor 1 (obsession: hoarding; compulsion: counting, repeating, hoarding, ordering) than did those with allele 3.00. CONCLUSIONS: The MAO-A gene may be associated with the development of OCD in males. Further study is necessary to evaluate the relationship between OCD and MAO-A genetic polymorphisms.
