The First Korean Case of Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium abscessus Subspecies bolletii in a Patient with Bronchiectasis.
- Author:
Byeong Ho JEONG
1
;
Su Young KIM
;
Kyeongman JEON
;
Hee Jae HUH
;
Chang Seok KI
;
Nam Yong LEE
;
Sung Jae SHIN
;
Won Jung KOH
Author Information
- Publication Type:Case Report
- Keywords: Bronchiectasis; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Sequence Analysis, DNA
- MeSH: Anti-Bacterial Agents; Bronchiectasis*; Clarithromycin; Follow-Up Studies; Humans; Lung Diseases*; Lung*; Male; Mycobacterium Infections, Nontuberculous; Mycobacterium*; Nontuberculous Mycobacteria; Sequence Analysis; Sequence Analysis, DNA; Sputum; Tuberculosis, Pulmonary
- From:Tuberculosis and Respiratory Diseases 2014;76(1):30-33
- CountryRepublic of Korea
- Language:English
- Abstract: We report the first Korean case of lung diseases caused by Mycobacterium abscessus subsp. bolletii in a previously healthy male, except for a previous history of pulmonary tuberculosis and bronchiectasis. All serial isolates are identified as M. abscessus subsp. bolletii by multi-locus sequence analysis based on the hsp65, rpoB, and 16S rRNA fragments. At the genetic level, the isolate has the erm(41) gene with a T28 sequevar, associated with clarithromycin resistance, and no rrl mutation. The isolate is resistant to clarithromycin. Although the symptoms and radiographic findings have improved after combination of antibiotics, the follow-up sputum cultures are persistently positive.
