A case of acetaminophen induced anaphylaxis without aspirin sensitivity.
- Author:
Yoon Jung KIM
1
;
Kum Hei RYU
;
Mina YU
;
Hee Jung OH
;
Chang Han PARK
;
Sun Hee MAENG
;
Young Joo CHO
Author Information
1. Departmemt of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea. yjcho@mm.ewha.ac.kr
- Publication Type:Case Report
- Keywords:
Drug hypersensitivity;
Acetaminophen;
Provocation test
- MeSH:
Acetaminophen*;
Adult;
Anaphylaxis*;
Angioedema;
Aspirin*;
Drug Hypersensitivity;
Exanthema;
Female;
Hand;
Humans;
Hypersensitivity;
Prescriptions;
Prostaglandin-Endoperoxide Synthases;
Pruritus;
Sensation;
Thorax;
Tongue;
Urticaria
- From:Korean Journal of Medicine
2003;65(Suppl 3):S926-S930
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acetaminophen is a world-wide used analgesic and anti-pyretic drug with less anti-in-flammatory effect, available without prescription in most countries. Allergic-like reactions to this drug, including urticaria, angioedema, and anaphylactic reactions have only rarely been reported. This report describes a systemic reaction to acetaminophen documented by oral provocation test in a 30-year-old female patient with a history of anaphylaxis associated with acetaminophen use, in a subject who tolerated aspirin. After an oral challenge with 108.3 mg of acetaminophen, the subject had itching sensation of tongue. With a dose of 162.5 mg (cumulative dose 270.8 mg) acetaminophen, systemic urticaria and rash developed. Also, hand and facial angioedema and chest tightness were noted. Significant change of FEV1 was not noted. But, this patient has bronchial hyperresponsiveness. A rare acute hypersensitivity reaction to acetaminophen without aspirin sensitivity is described in this study. The results of study suggest an other mechanism rather than inhibition of cyclooxygenase as responsible.
