The molecular mechanism for nuclear transport and its application.
- Author:
Yun Hak KIM
1
;
Myoung Eun HAN
;
Sae Ock OH
Author Information
- Publication Type:Review
- Keywords: Nuclear transport; Nucleoporins; Ran; Karyopherins; Nuclear localization signal
- MeSH: Active Transport, Cell Nucleus*; Carcinogenesis; Cell Physiological Processes; Cytoplasm; Gene Expression; Karyopherins; Nuclear Localization Signals; Nuclear Pore; Nuclear Pore Complex Proteins; Signal Transduction; Transportation
- From:Anatomy & Cell Biology 2017;50(2):77-85
- CountryRepublic of Korea
- Language:English
- Abstract: Transportation between the cytoplasm and the nucleoplasm is critical for many physiological and pathophysiological processes including gene expression, signal transduction, and oncogenesis. So, the molecular mechanism for the transportation needs to be studied not only to understand cell physiological processes but also to develop new diagnostic and therapeutic targets. Recent progress in the research of the nuclear transportation (import and export) via nuclear pore complex and four important factors affecting nuclear transport (nucleoporins, Ran, karyopherins, and nuclear localization signals/nuclear export signals) will be discussed. Moreover, the clinical significance of nuclear transport and its application will be reviewed. This review will provide some critical insight for the molecular design of therapeutics which need to be targeted inside the nucleus.
