Association between Antipsychotic-Induced Restless Legs Syndrome and Glutathione S-Transferase Gst-M1, Gst-T1 and Gst-P1 Gene Polymorphisms.
10.14401/KASMED.2015.22.1.25
- Author:
Seung Gul KANG
1
;
Young Min PARK
;
Leen KIM
;
Heon Jeong LEE
Author Information
1. Department of Psychiatry, Gil Medical Center, Gachon University, School of Medicine, Incheon, Korea.
- Publication Type:Original Article
- Keywords:
Restless legs syndrome;
Antipsychotics;
Schizophrenia;
Glutathione S-transferase genes;
Polymorphism
- MeSH:
Antipsychotic Agents;
Genotype;
Glutathione Transferase*;
Humans;
Movement Disorders;
Oxidative Stress;
Reactive Oxygen Species;
Restless Legs Syndrome*;
Schizophrenia
- From:Sleep Medicine and Psychophysiology
2015;22(1):25-29
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The pathophysiology of restless legs syndrome (RLS) has not been fully elucidated. Oxidative stress might play a role in the development of RLS and other antipsychotic-induced side effects such as tardive dyskinesia. In the present study, we investigated whether the glutathione S-transferase (GST) gene polymorphisms are associated with antipsychotic-induced RLS in schizophrenia. METHODS: We assessed antipsychotic-induced RLS symptoms in 190 Korean schizophrenic patients using the diagnostic criteria of the International Restless Legs Syndrome Study Group. The GST-M1, GST-T1 and GST-P1 loci were analyzed using PCR-based methods. RESULTS: We divided the subjects into 2 groups: those with RLS symptoms (n = 96) and those without RLS symptoms (n = 94). There were no significant differences in the distributions of the GST-M1 genotypes (chi2 = 3.56, p = 0.059), GST-T1 (chi2 = 0.51, p = 0.476) and GST-P1 (chi2 = 0.57, p = 0.821) between the 2 groups. Comparison of the RLS score among genotypes of the GST-M1 (t = -1.54, p = 0.125), GST-T1 (t = -0.02, p = 0.985) and GST-P1 (F = 0.58, p = 0.560) revealed no significant difference. CONCLUSION: These data suggest that GST gene polymorphisms do not confer increased susceptibility to RLS symptoms in schizophrenic patients. Future studies are necessary to evaluate the possible influences of other candidate genes involved in the reactive oxygen species system.
