Sclerotherapy of Renal Cysts in Korean ADPKD Patients.
- Author:
Jung Geon LEE
1
;
Cu Rie AHN
;
Sung Chul YOON
;
Jong Hoon PARK
;
Eun Kyong SONG
;
Yeong Hwan HWANG
;
Dae Yeon HWANG
;
Jung Hwan PARK
;
Se Han LEE
;
Se Jung KIM
;
Yon Su KIM
;
Jin Suk HAN
;
Suhng Gwon KIM
;
Jung Sang LEE
;
Seung Hyup KIM
Author Information
1. Department of Internal Medicine, Eulji Medical College, Korea.
- Publication Type:Original Article
- Keywords:
Autosomal dominant polycystic kidney disease;
Sclerotherapy;
ethanol;
n-butyl cyanoacrylate
- MeSH:
Adult;
Blood Urea Nitrogen;
Ethanol;
Ethiodized Oil;
Female;
Flank Pain;
Hemorrhage;
Humans;
Male;
Polycystic Kidney, Autosomal Dominant*;
Sclerotherapy*;
Tetracycline
- From:Korean Journal of Nephrology
2002;21(4):629-635
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Autosomal dominant polycystic kidney disease(ADPKD) is the most common hereditary renal disease in adults, and its major complaints include pain and abdominal fullness due to cyst expansion. So far, for the control of these symptoms, cyst ablation with ethanol or tetracycline, laparoscopic manipulations and surgical marsupialization have been used. METHODS: We used conventional ethanol(n=9) or n-butyl cyanoacrylate(NBCA) plus lipiodol solution (n=18) or both(n=3) for separate cysts as the sclerosing agent in 24 adult Korean ADPKD patients. And their clinical courses after treatment were evaluated. RESULTS: The male to female ratio was 8 : 16 and the mean age at the treatment was 50 yrs(S.D. 13.1). Causes for aspiration were pain in 14 and abdominal fullness in 7 patients and the range for the cyst diameters aspirated were 5-16 cm. Flank pain or discomfort were decreased subjectively in most cases except two. Mean arterial pressures(S.D.) (mmHg) before and after procedure were as follows 112(11.1)(basal), 96(9.6)(1 month) and 98(9.7)(6 month)(p < 0.05, paired-t test). Blood urea nitrogen levels(mg/dL) were not changed 6 month later[24 (12.1) vs. 22(14.6)]. There was no major complication such as bleeding or infection and no death and associated with procedure. There was no difference of therapeutic effect according to sclerosing agent. CONCLUSION: NBCA was as effective as conventional ethanol for sclerotherapy in ADPKD and cyst ablation therapy showed a BP-lowering effect in short-term period.
