A Case of Penicillium merneffei CAPD Peritonitis.
- Author:
Sang Hoon HAN
1
;
Hoon Young CHOI
;
Sang Cheol LEE
;
Young Suck GOO
;
Kyung Hee CHANG
;
Shin Wook KANG
;
Kyu Hyun CHOI
;
June Myung KIM
;
Ho Yung LEE
;
Dae Suk HAN
;
Young Dong EUN
;
Kyung Woon LEE
;
Jong Hee SHIN
Author Information
1. Department of Internal Medicine, Collage of Medicine, Yonsei University, Seoul, Korea. khchoi6@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Penicillium marneffei;
Continuous ambulatory peritoneal dialysis-associated peritonitis
- MeSH:
Bone Marrow;
China;
Diagnosis;
Diarrhea;
Early Diagnosis;
Fungemia;
Fungi;
Hong Kong;
Humans;
Immunocompromised Host;
Incidence;
Indonesia;
Korea;
Laos;
Lymphatic Diseases;
Malaysia;
Mortality;
Myanmar;
Penicillium*;
Peritoneal Dialysis, Continuous Ambulatory*;
Peritonitis*;
Polymerase Chain Reaction;
Singapore;
Skin;
Taiwan;
Thailand;
Vietnam
- From:Korean Journal of Nephrology
2002;21(4):680-685
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
P. marneffei is a fungus that causes life-threatening disseminated infection in a geographically distinct areas of the world. Following the first case of human infection in 1959, the incidence of this infection has risen markedly during the past 5 years. However, even in the midst of such rapid increase, the infection has always occurred only in a limited geographic distributions or in persons who have visited this limited geographic areas. These areas include Myanmar, Hong Kong, Indonesia, Laos, Malaysia, Singapore, Taiwan, Thailand, Vietnam, and the Guangxi province of southern China. P. marneffei infection occurs mostly in immunocompromised patients, particularly AIDS patients. P. marneffei infection commonly presents with skin and subcutanous tissue infection, fungemia, diarrhea, bone marrow infection, and generalized lymphadenopathy with hepatosplenomegaly. We report the case of continuous ambulatory peritoneal dialysis-associated peritonitis caused by P. marneffei. The case occurred in Korea, a non-endemic area of P. marneffei, in a non-AIDS patient who has not been exposed to any of the endemic areas. This warrants further consideration in determining the yet unknown transmission route of this fungal organism. P. marneffei was diagnosed without delay by 18sRNA PCR and sequencing, and was later confirmed by culture. PCR and sequencing may contribute to the early diagnosis of the P. marneffei infection, which is important given this infection's ability to progress to a systemic infection with high mortality rate when diagnosis and management are delayed.
