A Case of Antithyroid Drug-Induced Agranulocytosis Treated with Granulocyte Colony-Stimulating Factor (G-CSF) and Methylprednisolone.
- Author:
Tae Hoon EOM
;
Hye Jin JEOUN
;
Sang Min CHO
;
Min Ho JUNG
;
Byung Kyu SUH
;
Byung Churl LEE
- Publication Type:Case Report
- Keywords:
Agranmulocytosis;
Methimazole;
G-CSF
- MeSH:
Adolescent;
Agranulocytosis*;
Female;
Granulocyte Colony-Stimulating Factor*;
Granulocytes*;
Humans;
Methimazole;
Methylprednisolone*
- From:Journal of Korean Society of Pediatric Endocrinology
2004;9(1):81-85
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Although rare, agranulocytosis is the most serious, potentially fatal side effect of antithyroid drug. We experienced a 13-year-old girl who developed methimazole-induced agranulocytosis at 1 month after the initiation of treatment. Her granulocyte count recovered after discontinuation of methimazole and treatment with broad spectrum-antibiotics, G-CSF, and methylprednisolone. After recovery from agranulocytosis she was treated with radioiodine ablation therapy. Early detection and proper management of antithyroid drug-induced agranulocytosis is very important.
