Anti-hepatofibrogenic Effect of Turnip Water Extract on Thioacetamide-induced Liver Fibrosis.
- Author:
Lan LI
1
;
Dae Hun PARK
;
Yong Chun LI
;
Seung Kee PARK
;
Yun Lyul LEE
;
Hyon Min CHOI
;
Dae Sup HAN
;
Hyuck Joo YANG
;
Eun Hye LEE
;
Hyung Kwan JANG
;
Young Jin KIM
;
Ja June JANG
;
Min Jae LEE
Author Information
- Publication Type:Original Article
- Keywords: Turnip water extract; thioacetamide (TAA); hepatofibrogenic animal model; nodular formation
- MeSH: Bile Ducts; Brassica napus; Fibrosis; Korea; Ligation; Liver; Liver Cirrhosis; Liver Diseases; Water
- From:Laboratory Animal Research 2010;26(1):1-6
- CountryRepublic of Korea
- Language:Korean
- Abstract: Liver fibrosis is a chronic liver disease and lots of people in Korea are suffered. There are many efforts to find candidates to suppress liver fibrogenesis and several chemical-induced model or bile duct ligation model have been used to research and develop hepatic fibrogenic suppressor. From the previous study about functional effects of turnip which cultivated in Kangha Island, we got the feasibility which turnip might be able to inhibit heptatic fibrogenesis. TAA is a representative hepatic fibrosis inducer, repeated 7-weeks i.p. injection of it results in hepatic fibrosis. We compared the level of hepatic fibrosis in TAA-turnip group, TAA group, and vehicle control group. Nodules-formed by TAA were observed; they were rarely shown in vehicle control group, observed in most area in TAA group, but only shown in periportal regions in TAA-turnip group. These results were confirmed through Masson's trichrom stain; fibrous structures increased in TAA group (fibrosis score: 4) but significantly decreased in TAA-turnip group (fibrosis score: 2-3). In conclusion, we got the result that turnip water extract has a potency to protect TAA-induced hepatic fibrogenesis but it is necessary further study to find its mechanism.
