Doublecortin-immunoreactive Neuroblasts in Each Layer of the Main Olfactory Bulb After Transient Cerebral Ischemia in Gerbils.
10.5625/lar.2010.26.1.121
- Author:
Jung Hoon CHOI
1
;
Ki Yeon YOO
;
Ok kyu PARK
;
Choong Hyun LEE
;
In Koo HWANG
;
Hyung Cheul SHIN
;
Moo Ho WON
Author Information
1. Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon, Korea.
- Publication Type:Letter
- Keywords:
Doublecortin;
main olfactory bulb;
migration;
transient ischemia
- MeSH:
Adult;
Brain;
Gerbillinae;
Humans;
Ischemia;
Ischemic Attack, Transient;
Neurogenesis;
Neurons;
Olfactory Bulb
- From:Laboratory Animal Research
2010;26(1):121-125
- CountryRepublic of Korea
- Language:English
-
Abstract:
Neurogenesis in the adult brain occurs continuously throughout life. The main olfactory bulb (MOB) is the first central relay of the olfactory system. We examined proliferation of newly generated cells in each layer of the gerbil MOB after 5 min of transient cerebral ischemia using doublecortin (DCX), a marker of neuronal progenitors. Many DCX immunoreactive neuroblasts were found in the all layers of the MOBs of control and ischemia groups. Ten to 15 days after ischemia/reperfusion, no difference in numbers of DCX immunoreactive neuroblasts was found in the MOB. Thirty days after ischemia/reperfusion, significant increase of DCX immunoreactive cells was observed in all layers of ischemic MOB. This result indicates that neuroblasts increase in the MOB from 30 days after transient cerebral ischemia in gerbils.
