The Observation of Histologic Changes of Major Intrahepatic Bile Duct Epithelium in the Resected Liver Tissue with Hepatolithiasis.
- Author:
Woon Sup HAN
1
;
Sae Kyung CHOI
;
Sun Hee SUNG
Author Information
1. Department of Pathology, College of Medicine, Ewha Womans University, Seoul 158-710, Korea. woonshan@shinbiro.com
- Publication Type:Original Article
- Keywords:
Hepatolithiasis;
Dysplasia;
Cholangiocarcinoma;
Bile duct
- MeSH:
Bile Ducts;
Bile Ducts, Intrahepatic*;
Carcinogenesis;
Cholangiocarcinoma;
Epithelium*;
Hyperplasia;
Liver*
- From:Korean Journal of Pathology
2001;35(1):20-25
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The relationship between hepatoliths and cholangiocarcinoma is etiologically unclear. However, histogenetic sequencing with hyperplasia, dysplasia and carcinoma can occur in the bile ducts of hepatolithiasis. METHODS: We studied 55 cases of hepatolithiasis and examined the specimens of resected liver tissue with a microscope. The growth patterns of bile duct epithelium were divided into four types: flat, tufting, micropapillary and papillary. The dysplasia was also divided into low-grade dysplasia (LGD) and high-grade dysplasia (HGD). RESULTS: Of 55 cases of hepatolithiasis, 30 cases (54.6%) were of the flat pattern, 13 cases (23.6%) the micropapillary pattern, and 11 cases (20%) the tufting pattern. Epithelial hyperplasia was noted in only 36 cases (65.5%) in the large bile ducts, but dysplastic changes were found in 19 cases. Of 19 cases of dysplasia, LGD was present in 14 cases (25.5% of total 55 cases) an HGD in 5 cases (9% of total 55 cases). The epithelial hyperplasia showed histologic growth of the flat pattern in 29 cases out of 36 cases. But LGD (14 cases) had 6 cases of the tufting pattern and 7 cases of the micropapillary pattern. HGD (5 cases) revealed 4 cases of the micropapillary pattern with one case of the tufting pattern. CONCLUSION: This study suggests that sequences of hyperplasia, low-grade dysplasia and high-grade dysplasia can play a role in the carcinogenesis of bile duct epithelium in hepatolithiasis with the histologic pattern changing from flat to micropapillary growth.
