The Relationship of Serum Angiotensin Converting Enzyme (ACE), Angiotensin II and Clinical Markers in the Idiopathic Interstitial Pneumonia.
10.4046/trd.2002.52.5.506
- Author:
Sun Young KYUNG
1
;
Hye Sook HAHN
;
Suk Ho SONG
;
Jun Kyu HWANG
;
Young Hee LIM
;
Chang Hyeok AN
;
Gye Young PARK
;
Jung Woong PARK
;
Seong Hwan JEONG
;
Seung Yeon HA
;
Jae Woong LEE
Author Information
1. Division of Pulmonary Medicine, Thoracic surgery, Gachon Medical School Gil Medical Center, Incheon, Korea. jsw@ghil.com
- Publication Type:Case Report
- Keywords:
Idiopathic interstitial pneumonia;
Angiotensin converting enzyme;
Angiotensin II;
Fibrosis
- MeSH:
Angiotensin II*;
Angiotensins*;
Apoptosis;
Biomarkers*;
Biopsy;
Bronchoalveolar Lavage Fluid;
Bronchoscopy;
Capillaries;
Dyspnea;
Epithelium;
Fibroblasts;
Fibrosis;
Humans;
Idiopathic Interstitial Pneumonias*;
Lung;
Peptidyl-Dipeptidase A*;
Pneumonia;
Pulmonary Fibrosis;
Reference Values;
Respiratory Function Tests;
Schools, Medical
- From:Tuberculosis and Respiratory Diseases
2002;52(5):506-518
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: There have been several studies showing that angiotensin II and the angiotensin convertingenzyme (ACE) contribute to the activation of fibroblast including the pulmonary fibrosis, and apoptosis of the al veolar epithelium in idiopathic intersititial pneumonia. This study was performed to identify the relationship between the serum angiotensin II. ACE and the pulmonary function test (PFT), the dyspnea score, and the cell fraction of the bronchoalveolar lavage fluid (BALF). METHODS: Twenty three patients with idiopathic interstitial pneumonia from March, 1999 to October, 2001 at Gachon medical school were enrolled in this study. They were divided into IPF(UIP) (16) and NSIP (7) group. Twelve of the idiopathic interstitial pneumonia patients (UIP : 5, NSIP: 7) were diagnosed by an open lung biopsy, 11 of IPF patients were diagnosed by the American Thoracic Society (ATS) diagnostic criteria. The PFT values, dyspnea score, serum ACE and angiotensin II were measured, and a bronchoscopy was performed to obtain the BALF. RESULTS: Of all the patients, 7 were in the normal range and 14 showed an increase in the serum level of angiotensin II. In terms of the serum ACE level, 14 patients had an increased level. The DLCO% of the angiotensin II. increased group was significantly lower than the not-increased group (p=0.021). Other factors did not correlate with the serum ACE or the angiotensin II increased group and not-increased group. CONCLUSION: These results suggest that an increased angiotensinII serum level may be associated with in crease in the of alveolar capillary block in the progression of pulmonary fibrosis in idiopathic interstitial pneumonia.
