Effects of Na+, K(+)-pump inhibitors on acetylcholine-induced relaxation in the rabbit aorta.
- Author:
Young Ho LEE
1
;
Duck Sun AHN
;
Hae Jin SONG
;
Yoon Hi KIM
;
Hyun Sook KIM
;
Soon Hee AHN
;
Bok Soon KANG
Author Information
- Publication Type:Original Article ; In Vitro ; Research Support, Non-U.S. Gov't
- Keywords: vascular smooth muscle; endothelium-dependent relaxation; Na+; K+-pump
- MeSH: Acetylcholine/*pharmacology; Animal; Aorta/drug effects/physiology; Endothelium, Vascular/physiology; In Vitro; Na(+)-K(+)-Exchanging ATPase/drug effects/*physiology; Nitroprusside/pharmacology; Ouabain/pharmacology; Rabbits; Support, Non-U.S. Gov't; Vasodilation/*drug effects
- From:Yonsei Medical Journal 1992;33(1):8-13
- CountryRepublic of Korea
- Language:English
- Abstract: The purpose of this study was to investigate the effects of inhibitors of the Na+, K(+)-pump and membrane depolarizing agents on endothelium-dependent acetylcholine-induced relaxation in the rabbit thoracic aorta. Aortic rings were prepared from the rabbit descending thoracic aorta and the contractility of the ring was measured in various conditions such as application of ouabain, exposure to K(+)-free Krebs-Henseleit solution and high K+. Ouabain or exposure to K(+)-free Krebs-Henseleit solution inhibited acetylcholine or sodium nitroprusside-induced relaxation. KCl also inhibited the acetylcholine or sodium nitroprusside-induced relaxation. These results suggest that the Na+, K(+)-pump may play a role in endothelium-dependent acetylcholine-induced relaxation.
