Sequencing the nucleotides of third exon of alpha-synuclein gene from Vienamese persons with Parkinson’s disease
- Author:
Hoa Quynh Do
- Publication Type:Journal Article
- Keywords:
Parkinson
- MeSH:
alpha-Synuclein;
Parkinson Disease
- From:Journal of Practical Medicine
2002;435(11):23-25
- CountryViet Nam
- Language:Vietnamese
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Abstract:
The third exon of the synuclein gene from a normal person and two Vietnamese persons with Prkinson’s disease was subcloned and sequenced. It was shown that in all cases there are two additional bases in the positions of C461 and T511. That is quite different from the sequence with DDBJ/Genbank accession number U46898. Besides, a mutation T543G was revealed in one Parkinson’s disease patien. All mentioned changes were located outside the region coding for third exon (G401-G442).
