Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation.
- Author:
In Hyuk JUNG
1
;
You Han LEE
;
Ji Young YOO
;
Se Jin JEONG
;
Seong Keun SONN
;
Jong Gil PARK
;
Keun Ho RYU
;
Bong Yong LEE
;
Hye Young HAN
;
So Young LEE
;
Dae Yong KIM
;
Hang LEE
;
Goo Taeg OH
Author Information
1. Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, Korea. gootaeg@ewha.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
atherosclerosis;
cilostazol;
cytokines;
disease models, animal;
Ginkgo biloba;
inflammation;
macrophages;
reactive oxygen species
- MeSH:
Animals;
Apolipoproteins E/genetics/physiology;
Atherosclerosis/*drug therapy;
Cytokines/metabolism;
Disease Models, Animal;
Drug Synergism;
Ginkgo biloba/*chemistry;
Humans;
Macrophages/cytology/drug effects;
Male;
Mice;
Mice, Nude;
Plant Extracts/*administration & dosage/chemistry;
Reactive Oxygen Species/*metabolism;
Tetrazoles/*administration & dosage
- From:Experimental & Molecular Medicine
2012;44(5):311-318
- CountryRepublic of Korea
- Language:English
-
Abstract:
In this study, the synergistic effect of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone (cilostazol) and Ginkgo biloba extract (GbE) was examined in apolipoprotein E (ApoE) null mice. Co-treatment with GbE and cilostazol synergistically decreased reactive oxygen species (ROS) production in ApoE null mice fed a high-fat diet. Co-treatment resulted in a significantly decreased atherosclerotic lesion area compared to untreated ApoE mice. The inflammatory cytokines and adhesion molecules such as monocyte chemoattractant-1 (MCP-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and VCAM-1 which can initiate atherosclerosis were significantly reduced by the co-treatment of cilostazol with GbE. Further, the infiltration of macrophages into the intima was decreased by co-treatment. These results suggest that co-treatment of GbE with cilostazol has a more potent anti-atherosclerotic effect than treatment with cilostazol alone in hyperlipidemic ApoE null mice and could be a valuable therapeutic strategy for the treatment of atherosclerosis.
