The Relationship between the SNAP-25 Polymorphism and Omission Errors in Korean Children with Attention Deficit Hyperactivity Disorder.
10.9758/cpn.2017.15.3.222
- Author:
Eunjoo KIM
1
;
Dong Ho SONG
;
Nam Wook KIM
;
In Jung SOHN
;
Keun Ah CHEON
Author Information
1. Department of Psychiatry and Institute of Behavioral Science in Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Attention deficit disorder with hyperactivity;
SNAP-25;
Continuous performance test;
Omission errors
- MeSH:
Attention Deficit Disorder with Hyperactivity*;
Child*;
Genotype;
Humans;
Phenotype;
Reaction Time;
Sample Size;
Synaptosomal-Associated Protein 25
- From:Clinical Psychopharmacology and Neuroscience
2017;15(3):222-228
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: This study aimed to investigate the association between the synaptosomal-associated protein 25 kDa (SNAP-25) genotype and performance on the continuous performance test (CPT) in Korean children with attention-deficit/hyperactivity disorder (ADHD). METHODS: Eighty-seven children with ADHD (mean age, 9.23±1.99 years) participated in this study. Omission errors, commission errors, reaction time, and reaction time variability on the CPT were analyzed. The single-nucleotide polymorphism (SNP) rs3746544 (1065 T>G) of SNAP-25 was genotyped to examine the association with CPT performance. RESULTS: We found significantly more omission errors on the CPT among children with the TT genotype of SNAP-25 (t=2.56, p=0.012) after correcting for multiple testing. CONCLUSION: Our results suggest the possible involvement of the SNAP-25 1065 T>G polymorphism in the inattention phenotype in children with ADHD. Further studies with more refined neuropsychological measures and much larger sample sizes are needed to confirm our findings.
