Plasma Levels of Tumor Necrosis Factor Superfamily Molecules Are Increased in Bipolar Disorder.
10.9758/cpn.2017.15.3.269
- Author:
Izabela G BARBOSA
1
;
Gabriela Neves VAZ
;
Natalia Pessoa ROCHA
;
Rodrigo MACHADO-VIEIRA
;
Marcio Rogerio Diniz VENTURA
;
Rodrigo B HUGUET
;
Moises E BAUER
;
Michael BERK
;
Antônio L TEIXEIRA
Author Information
1. Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil. izabelagb@gmail.com, altexr@gmail.com
- Publication Type:Original Article
- Keywords:
Bipolar disorder;
TNF-α;
TWEAK;
TRAIL;
sTNFR
- MeSH:
Apoptosis;
Bipolar Disorder*;
Comorbidity;
Depression;
Enzyme-Linked Immunosorbent Assay;
Humans;
Inflammation;
Plasma*;
Receptors, Tumor Necrosis Factor;
TNF-Related Apoptosis-Inducing Ligand;
Tumor Necrosis Factor-alpha*
- From:Clinical Psychopharmacology and Neuroscience
2017;15(3):269-275
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD. METHODS: Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the Hamilton Depression Rating Scale to evaluate manic and depressive symptoms severity, respectively. TNF superfamily molecules (TNF, TNF-related weak inducer of apoptosis [TWEAK], TNF-related apoptosis-inducing ligand [TRAIL], soluble TNF receptor type 1 [sTNFR1], and soluble TNF receptor type 2 [sTNFR2]) levels were measured by ELISA. RESULTS: Patients with BD, regardless of mood state, presented increased plasma levels of sTNFR1 and TWEAK in comparison with controls. CONCLUSION: These findings corroborate the view that TNF superfamily may play a role in BD pathophysiology.
