The Effect of Pomegranate on Depression, Anxiety, and Food Intake in Ovariectomized Rats.
- Author:
Ki Hoon AHN
1
;
Kyong Wook YI
;
Hyun Tae PARK
;
Jung Ho SHIN
;
Jun Young HUR
;
Young Tae KIM
;
Sun Haeng KIM
;
Kyu Wan LEE
;
Seung Hee KIM
;
Chun Sik BAE
;
Tak KIM
Author Information
1. Department of Obstetrics and Gynecology, Korea University Anam Hospital, Korea University College of Medicine, Korea. tkim@kumc.or.kr
- Publication Type:Original Article
- Keywords:
Pomegranate;
Depression;
Anxiety;
Food intake
- MeSH:
Animals;
Anxiety;
Arm;
Depression;
Eating;
Female;
Humans;
Hyperphagia;
Ovariectomy;
Punicaceae;
Rats;
Rats, Sprague-Dawley;
Salicylamides
- From:The Journal of Korean Society of Menopause
2010;16(1):39-45
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: To determine whether or not pomegranate extract can affect depression, anxiety, and food intake in ovariectomized rats. METHODS: Seventy-nine female Sprague-Dawley rats were divided into six groups: A, no operation and no drug intake; B, sham operation and distilled water; C, ovariectomy and distilled water; D, ovariectomy and 10% dilute pomegranate extract; E, ovariectomy and 20% dilute pomegranate extract; and F, ovariectomy and 40% dilute pomegranate extract. Beginning 2 days after surgery, drugs were administrated for 4 weeks. After that, the rats were subjected to the elevated plus maze (EPM) test and forced swim test (FST). RESULTS: The 10% pomegranate extract had a lower % closed arm entry frequency in the EPM test. A pomegranate dose-dependent decrease in the duration of immobility duration in FST was shown. Pomegranate did not reverse ovariectomy-related hyperphagia and weight gain. CONCLUSION: Pomegranate extract improved depression and anxiety in a postmenopausal model with ovariectomized rats.
