A Rare Case of Microgranular Acute Promyelocytic Leukemia Associated with ider(17)(q10)t(15;17) in an Old-age Patient.
10.3343/kjlm.2011.31.2.86
- Author:
Min Jin KIM
1
;
Sun Young CHO
;
Gayoung LIM
;
Hoi Soo YOON
;
Hee Joo LEE
;
Jin Tae SUH
;
Juhie LEE
;
Woo In LEE
;
Kyung Sam CHO
;
Tae Sung PARK
Author Information
1. Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Korea. 153jesus@hanmail.net
- Publication Type:Case Report ; Research Support, Non-U.S. Gov't
- Keywords:
ider(17)(q10)t(15;
17);
Old-age;
Microgranular;
Acute promyelocytic leukemia
- MeSH:
Bone Marrow Cells/pathology;
*Chromosomes, Human, Pair 15;
*Chromosomes, Human, Pair 17;
Female;
Humans;
In Situ Hybridization, Fluorescence;
Karyotyping;
Leukemia, Promyelocytic, Acute/*diagnosis/genetics/pathology;
Middle Aged;
Oncogene Proteins, Fusion/genetics;
*Translocation, Genetic
- From:The Korean Journal of Laboratory Medicine
2011;31(2):86-90
- CountryRepublic of Korea
- Language:English
-
Abstract:
We present a rare case of microgranular variant acute promyelocytic leukemia (APL) associated with ider(17)(q10)t(15;17)(q22;q12) of an old-age patient. The initial chromosome study showed a 46,XX,del(6)(?q21q25),der(15)t(15;17)(q22;q12),ider(17)(q10)t(15;17)[10]/47,sl,+ider(17)(q10)t(15;17)[3]/46,XX[16]. FISH signals from a dual color dual fusion translocation PML-RARA probe were consistent with the results of conventional cytogenetics. Because of the rarity of ider(17)(q10)t(15;17) in microgranular APL, further studies on both gene dosage effect of this chromosomal abnormality and the influence of ider(17)(q10)t(15;17) on clinical features such as prognosis, survival, and treatment response of APL cases are recommended.
