Relationship between the hepatic venous pressure gradient and first variceal hemorrhage in patients with cirrhosis: a multicenter retrospective study in Korea.
10.3350/cmh.2012.18.4.391
- Author:
Jin Nyoung KIM
1
;
Kyoung Min SOHN
;
Moon Young KIM
;
Ki Tae SUK
;
Soung Won JEONG
;
Ho Eun JUNG
;
Sae Hwan LEE
;
Sang Gyune KIM
;
Jae Young JANG
;
Young Seok KIM
;
Soon Koo BAIK
;
Hong Soo KIM
;
Dong Joon KIM
;
Boo Sung KIM
Author Information
1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea. jyjang@schmc.ac.kr
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Hepatic venous pressure gradient (HVPG);
Variceal hemorrhage
- MeSH:
Adult;
Catheters;
Esophageal and Gastric Varices/*complications;
Female;
Gastrointestinal Hemorrhage/*etiology;
Humans;
Liver Cirrhosis/*complications/mortality;
Male;
Middle Aged;
Republic of Korea;
Retrospective Studies;
Severity of Illness Index;
*Venous Pressure
- From:Clinical and Molecular Hepatology
2012;18(4):391-396
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Variceal hemorrhage is one of the major complications of cirrhosis and is associated with significant mortality and morbidity. The development of gastroesophageal varices and variceal hemorrhage is the most direct consequence of portal hypertension. Correlations between the hepatic venous pressure gradient (HVPG) and first variceal hemorrhage were examined. METHODS: Patients with cirrhosis who underwent HVPG measurement between July 2009 and September 2010 were enrolled (n=535). All patients underwent esophagogastroduodenoscopy to enable the evaluation of gastroesophageal varices. RESULTS: The HVPG for all patients was 16.46+/-7.05 mmHg (mean+/-SD), and was significantly higher among those with first variceal hemorrhage than in those without it. The HVPG was significantly correlated with both Child-Turcotte-Pugh (r=0.488, P<0.001) and Model for End-stage Liver Disease (r=0.478, P<0.001) scores. An HVPG value of 11 mmHg was predictive of first variceal hemorrhage with a sensitivity of 92.4% and a specificity of 27.7%. CONCLUSIONS: The HVPG was higher in patients with first variceal hemorrhage than in those without it.
