The Influences of Clonidine Premedication on the A-lineTM ARX Index and Hemodynamics during Anesthesia Induction with Propofol.
10.4097/kjae.2003.45.1.13
- Author:
Won Jin CHOI
1
;
Woo Jae JEON
;
Jae Hang SHIM
;
Sang Yoon CHO
;
Jong Hoon YEOM
;
Woo Jong SHIN
;
Kyoung Hun KIM
Author Information
1. Department of Anesthesiology, College of Medicine, Hanyang University, Seoul, Korea. goldnan@hanyang.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
alpha2-adrenoreceptor agonist;
A-lineTM ARX index (AAI);
clonidine
- MeSH:
Anesthesia*;
Arterial Pressure;
Blood Pressure;
Bradycardia;
Clonidine*;
Double-Blind Method;
Heart Rate;
Hemodynamics*;
Humans;
Hypnotics and Sedatives;
Injections, Intravenous;
Intubation;
Intubation, Intratracheal;
Premedication*;
Propofol*;
Prospective Studies
- From:Korean Journal of Anesthesiology
2003;45(1):13-21
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND:Clonidine, an alpha2-adrenergic receptor agonist, has been shown to have a sedative effect and to suppress hemodynamics when used as a premedicant. We evaluated the change of AEP index and hemodynamics after clonidine premedication and induction with propofol. METHODS:The study design was a prospective, randomized, double-blind study. 90 patients who were scheduled for elective surgery were randomly assigned in 3 groups (Group 1, 2 and 3). In groups 2 and 3, the patients were administered 2 microgram/kg or 4 microgram/kg of i.v. clonidine 30 minutes before the induction of propofol anesthesia, respectively. We measured A-lineTM ARX index (AAI), systolic blood pressure, mean arterial pressure, diastolic blood pressure and heart rate at the ward; before the administration of clonidine premedication, before induction, just before intubation and 1 minute after endotracheal intubation, and compared these parameters among the 3 groups. RESULTS:Each dose of clonidine had a suppressive effect before the induction of anesthesia and suppressed hemodynamics successfully during intubation. In groups 2 and 3, the AAI was lower than in group 1 (P < 0.05), but 7 patients had bradycardia and 3 patients had been hypotensive in group 3. CONCLUSIONS: Intravenous injection of 2 microgram/kg clonidine as a premedicant reduced AAI significantly (P < 0.05) compared to the control group, with good hemodynamic stability. Therefore, we believe that AAI can be used to predict hypnotic state during propofol anesthesia.
