The Effect of Intravenous Ketamine on Recovery from Total Intravenous Anesthesia with Propofol.
10.4097/kjae.2003.45.1.37
- Author:
Sang Bum KIM
1
;
Hee Jin PARK
;
Sang Tae KIM
;
Hoon KANG
;
Seung Woon LIM
Author Information
1. Department of Anesthesiology and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju, Korea. kimst@med.chungbuk.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
ketamine;
propofol;
total intravenous anesthesia;
recovery
- MeSH:
Anesthesia, Intravenous*;
Arterial Pressure;
Blood Pressure;
Ear Ossicles;
Hallucinations;
Heart Rate;
Humans;
Ketamine*;
Propofol*;
Recovery Room;
Tympanoplasty
- From:Korean Journal of Anesthesiology
2003;45(1):37-41
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The aim of this study was to evaluate the effects of the continuous infusion of ketamine on recovery characteristics after total intravenous anesthesia (TIVA) with propofol. METHODS: Fifty-six patients undergoing tympanoplasty were randomly allocated to group I (control, n = 20), group II (ketamine 0.3 microgram/ml, n = 16) or group III (ketamine 0.6 microgram/ml, n = 20). Ketamine and propofol were continuously administered by using target-controlled infusion (TCI) at different ketamine steady-state concentrations. Blood pressure, heart rate and the time interval from the discontinuation of propofol to eye opening and discharge were measured. RESULTS: The changes in mean arterial pressure and heart rate before and after auditory ossicles movement examination were larger in group I than in group II or in group III (P <0.05). And, the times to eye opening and to discharge from the recovery room were longer in group II and group III than in group I (P <0.05). Hallucination occurred only in seven patients of group III. CONCLUSIONS: Groups II and III were more stable hemodynamically than group I, but patients in groups II and III required a longer recovery time than group I. No hallucination was found in groups I and II. We conclude that when ketamine is administered in combination with propofol, a lesser concentration than 0.3 microgram/ml of ketamine or early discontinuation of ketamine infusion appear to be appropriate.
