Transcription factors in the maintenance and survival of primordial follicles.
10.5653/cerm.2012.39.4.127
- Author:
Eun Jin LIM
1
;
Youngsok CHOI
Author Information
1. Department of Biomedical Science, CHA University, Seoul, Korea. youngsokchoi@cha.ac.kr
- Publication Type:Review
- Keywords:
Primordial follicles;
Transcription factors;
Figla;
Lhx8;
Nobox;
Sohlh1;
Sohlh2
- MeSH:
Female;
Fertility;
Humans;
Infertility;
Oocytes;
Ovary;
Parturition;
Transcription Factors
- From:Clinical and Experimental Reproductive Medicine
2012;39(4):127-131
- CountryRepublic of Korea
- Language:English
-
Abstract:
Primordial follicles are formed prenatally in mammalian ovaries, and at birth they are fated to be activated to primary follicles, to be dormant, or to die. During the early stage of folliclulogenesis, the oocyte undergoes dynamic alterations in expression of numerous genes, which are regulated by transcription factors. Several germ-cell specific transcriptional regulators are critical for formation and maintenance of follicles. These transcriptional regulators include: Figla, Lhx8, Nobox, Sohlh1, and Sohlh2. A subset of these transcriptional regulators is mutated in women with ovarian insufficiency and infertility. Establishment of this oocyte pool is essential for fertility. This review focuses on these transcriptional regulators of female primordial follicles.
