Methotrimeprazine-induced Corneal Deposits and Cataract Revealed by Urine Drug Profiling Test.
10.3346/jkms.2010.25.11.1688
- Author:
Seong Taeck KIM
1
;
Jae Woong KOH
;
Joon Mo KIM
;
Won Young KIM
;
Gwang Ju CHOI
Author Information
1. Department of Ophthalmology, Chosun University College of Medicine, Gwangju, Korea. clearcornea@paran.com
- Publication Type:Case Reports
- Keywords:
Methotrimeprazine;
Cornea Deposits;
Cataract
- MeSH:
Adult;
Antipsychotic Agents/*adverse effects/therapeutic use/urine;
Cataract/*chemically induced;
Corneal Diseases/*chemically induced;
Female;
Humans;
Male;
Mental Retardation/diagnosis/drug therapy;
Methotrimeprazine/*adverse effects/therapeutic use/urine;
Middle Aged;
Schizophrenia/diagnosis/drug therapy;
Visual Acuity
- From:Journal of Korean Medical Science
2010;25(11):1688-1691
- CountryRepublic of Korea
- Language:English
-
Abstract:
Two schizophrenic patients who had been taking medication for a long period presented with visual disturbance of 6-month duration. Slit-lamp examination revealed fine, discrete, and brownish deposits on the posterior cornea. In addition, bilateral star-shaped anterior subcapsular lens opacities, which were dense, dust-like granular deposits, were noted. Although we strongly suspected that the patient might have taken one of the drugs of the phenothiazine family, we were unable to obtain a history of medications other than haloperidol and risperidone, which were taken for 3 yr. We performed a drug profiling test using urine samples and detected methotrimeprazine. The patient underwent surgery for anterior subcapsular lens opacities. Visual acuity improved in both eyes, but the corneal deposits remained. We report an unusual case of methotrimeprazine-induced corneal deposits and cataract in a patient with psychosis, identified by using the urine drug profiling test.
