Probiotics in the Prevention and Treatment of Postmenopausal Vaginal Infections: Review Article.
10.6118/jmm.2017.23.3.139
- Author:
Jun Mo KIM
1
;
Yoo Jin PARK
Author Information
1. Department of Urology, Soonchunhyang University College of Medicine, Bucheon, Korea. urojun@schmc.ac.kr
- Publication Type:Review
- Keywords:
Candidiasis, vulvovaginal;
Postmenopause;
Probiotics;
Vaginal diseases;
Vaginosis, bacterial
- MeSH:
Candida;
Candidiasis, Vulvovaginal;
Colon;
Enterobacter;
Escherichia coli;
Estrogens;
Female;
Glycogen;
Humans;
Hydrogen-Ion Concentration;
Lactic Acid;
Lactobacillus;
Microbiota;
Odors;
Postmenopause;
Premenopause;
Probiotics*;
Progesterone;
Vagina;
Vaginal Discharge;
Vaginal Diseases;
Vaginosis, Bacterial
- From:Journal of Menopausal Medicine
2017;23(3):139-145
- CountryRepublic of Korea
- Language:English
-
Abstract:
Bacterial vaginosis (BV) and complicated vulvovaginal candidiasis (VVC) are frequently occurring vaginal infections in postmenopausal women, caused by an imbalance in vaginal microflora. Postmenopausal women suffer from decreased ovarian hormones estrogen and progesterone. A normal, healthy vaginal microflora mainly comprises Lactobacillus species (spp.), which act beneficially as a bacterial barrier in the vagina, interfering with uropathogens. During premenopausal period, estrogen promotes vaginal colonization by lactobacilli that metabolizing glycogen and producing lactic acid, and maintains intravaginal health by lowering the intravaginal pH level. A lower vaginal pH inhibits uropathogen growth, preventing vaginal infections. Decreased estrogen secretion in postmenopausal women depletes lactobacilli and increases intravaginal pH, resulting in increased vaginal colonization by harmful microorganisms (e.g., Enterobacter, Escherichia coli, Candida, and Gardnerella). Probiotics positively effects on vaginal microflora composition by promoting the proliferation of beneficial microorganisms, alters the intravaginal microbiota composition, prevents vaginal infections in postmenopausal. Probiotics also reduce the symptoms of vaginal infections (e.g., vaginal discharge, odor, etc.), and are thus helpful for the treatment and prevention of BV and VVC. In this review article, we provide information on the intravaginal mechanism of postmenopausal vaginal infections, and describes the effectiveness of probiotics in the treatment and prevention of BV and VVC.
