Generalized Pustular Psoriasis and Hepatic Dysfunction Associated with Oral Terbinafine Therapy.
10.3346/jkms.2007.22.1.167
- Author:
Byung Soo KIM
1
;
Ho Sun JANG
;
Seung Wook JWA
;
Bong Seok JANG
;
Moon Bum KIM
;
Chang Keun OH
;
Yoo Wook KWON
;
Kyung Sool KWON
Author Information
1. Department of Dermatology, Pusan National University College of Medicine, Busan, Korea, Korea. hsjang@pusan.ac.kr
- Publication Type:Case Report ; Review
- Keywords:
Psoriasis;
Generalized Pustular Psoriasis;
Liver Diseases;
terbinafine
- MeSH:
Suppuration/chemically induced;
Psoriasis/*chemically induced;
Naphthalenes/*adverse effects;
Middle Aged;
Male;
Liver Diseases/*chemically induced;
Humans;
Antifungal Agents/*adverse effects;
Administration, Oral
- From:Journal of Korean Medical Science
2007;22(1):167-169
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of 61-yr-old man with stable psoriasis who progressively developed generalized pustular eruption, erythroderma, fever, and hepatic dysfunction following oral terbinafine. Skin biopsy was compatible with pustular psoriasis. After discontinuation of terbinafine and initiating topical corticosteroid and calcipotriol combination with narrow band ultraviolet B therapy, patient's condition slowly improved until complete remission was reached 2 weeks later. The diagnosis of generalized pustular psoriasis (GPP) induced by oral terbinafine was made. To our knowledge, this is the first report of GPP accompanied by hepatic dysfunction associated with oral terbinafine therapy.
