A Case of Acute Promyelocytic Leukemia with a De novo t(11;19) Chromosomal Translocation.
- Author:
Sung Yeon CHO
1
;
Ju Youn KIM
;
Ju Yeon HEO
;
Seong Jin LEE
;
Chi Wha HAN
;
Je Hoon LEE
Author Information
1. Department of Internal Medicine, St. Mary's Hospital, The Catholic University of Korea School of Medicine, Seoul, Korea. cwhan@unitel.co.kr
- Publication Type:Case Report
- Keywords:
Acute promyelocytic leukemia;
Chromosomal translocation;
Molecular pathology
- MeSH:
Disseminated Intravascular Coagulation;
Leukemia;
Leukemia, Promyelocytic, Acute;
Pathology, Molecular;
Prognosis;
Translocation, Genetic;
Tretinoin
- From:Korean Journal of Medicine
2011;80(Suppl 2):S268-S272
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acute promyelocytic leukemia (APL), which is usually defined by the morphological features of the leukemic cells, is characterized by the t(15;17) (q22;q21) chromosomal translocation and disseminated intravascular coagulation. This specific translocation results in a new fusion transcript between the promyelocytic leukemia (PML) gene and the retinoic acid receptor-alpha (RARalpha) gene. Although the presence of this fusion gene can predict a favorable clinical response to all-trans-retinoic-acid (ATRA) treatment, APL with chromosomal translocations other than t(15;17) (q22;q21) is extremely rare and is associated with a poor prognosis. We experienced a case of APL with de novo t(11;19).
