Klotho and the Aging Process.
10.3904/kjim.2011.26.2.113
- Author:
Makoto KURO-O
1
Author Information
1. Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, USA. Makoto.Kuro-o@UTSouthwestern.edu
- Publication Type:Review
- Keywords:
Klotho;
Fibroblast growth factor;
Phosphate;
Vitamin D
- MeSH:
Aging/genetics/*metabolism;
Animals;
Chronic Disease;
Fibroblast Growth Factors/metabolism;
Glucuronidase/genetics/*metabolism;
Homeostasis;
Humans;
Kidney Diseases/metabolism/physiopathology;
Phenotype;
Phosphates/metabolism;
Phosphorus, Dietary/metabolism;
*Signal Transduction
- From:The Korean Journal of Internal Medicine
2011;26(2):113-122
- CountryRepublic of Korea
- Language:English
-
Abstract:
The klotho gene was originally identified as a putative age-suppressing gene in mice that extends life span when overexpressed. It induces complex phenotypes resembling human premature aging syndromes when disrupted. The gene was named after a Greek goddess Klotho who spun the thread of life. Since then, various functional aspects of the klotho gene have been investigated, leading to the identification of multiple novel endocrine axes that regulate various metabolic processes and an unexpected link between mineral metabolism and aging. The purposes of this review were to overview recent progress on Klotho research and to discuss a novel aging mechanism.
