A comparative study for guided bone regeneration of silk fibroin nanomembrane(NanoGide-S(TM)).
10.5051/jkape.2008.38.3.475
- Author:
Dae hyun HAN
1
;
Ki Seok HONG
;
Chin Hyung CHUNG
;
Sung Bin YIM
Author Information
1. Department of Periodontology, School of Dentistry, Dan Kook University, Korea. periohong@dankook.ac.kr
- Publication Type:Comparative Study ; Original Article
- Keywords:
Silk fibroin nanomembrane;
guided bone regeneration
- MeSH:
Axis, Cervical Vertebra;
Bone Regeneration;
Bone Resorption;
Chronic Periodontitis;
Dental Occlusion;
Fibroins;
Humans;
Periodontitis;
Silk;
Tooth;
Ulcer
- From:The Journal of the Korean Academy of Periodontology
2008;38(3):475-482
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the safety and efficiency of bone regenerative abilities of silk fibroin nanomembrane(Nanoguide-S) MATERIAL AND METHODS: The objects were 38 patients who had large defect at extraction sockets caused by chronic periodontitis and silk fibroin nano matrix were used on experimental group(N=19) and PLA/PLGA matrix were used on control group(N=19). The width, height, and length by crown-apical direction(socket depth) of defects were measured with the occlusal plane as a reference plane, and tooth axis direction, perpendicular to tooth axis direction were measured on radiographs at 3 months pre-operative, 3 months post-operative. RESULT: Tissue response to silk fibroin nano matrix and Biomesh were clinically satisfactory and complications such as swelling, exudation, ulceration and vesicles were not found except the ordinary discomfort of operated portion. 3 months later, the width, height, and length by crown-apical direction (socket depth) of defects were clinically improved in both groups with no significant difference. 3 months later radiolucency of tooth axis direction and perpendicular to tooth axis direction were all increased in both groups with no significant difference. CONCLUSION: By these results biodegradadable silk fibroin nano matrix was efficient in GBR on alveolar bone resorption caused by periodontitis compared to Biomesh.
