Peutz-Jeghers syndrome with germline mutation of STK11.
10.4174/astr.2014.86.6.325
- Author:
Hyun Dong CHAE
1
;
Chang Ho JEON
Author Information
1. Department of Surgery, Catholic University of Daegu School of Medicine, Daegu, Korea. hdchae@cu.ac.kr
- Publication Type:Case Report
- Keywords:
Peutz-Jeghers syndrome;
Intussusceptions;
STK11
- MeSH:
Child;
Female;
Germ-Line Mutation*;
Humans;
Incidence;
Intestine, Small;
Intussusception;
Lentigo;
Peutz-Jeghers Syndrome*;
Polyps;
Protein-Serine-Threonine Kinases
- From:Annals of Surgical Treatment and Research
2014;86(6):325-330
- CountryRepublic of Korea
- Language:English
-
Abstract:
Peutz-Jeghers syndrome (PJS), also known as periorificial lentiginosis, is a rare autosomal dominant inherited disease with an incidence of 1/200,000 live-borns. Mutations in the serine-threonine kinase 11 (STK11) gene are considered the major cause of PJS. The most frequent complication at young age is recurrent intussusception due to multiple hamartomatous polyps, primarily in the small intestine. Although extremely rare, the small bowel should be fully examined to be certain additional intussusceptions are not present. Herein, we report on a case of PJS with germline mutation of STK11 in a 12-year-old young girl who presented as a rare case of two small intestinal intussusceptions and review the literature.
