Activity of Cytokines and Expression of CD62L in Patients with Bronchial Asthma.
- Author:
Kwang Seon SONG
1
;
Won Yeon LEE
;
Ae Ra HONG
;
Hee Sun KIM
;
Suk Joong YONG
;
Kye Chul SHIN
Author Information
- Publication Type:Original Article
- Keywords: Atopic asthma; CD62L(L-selectin); Interleukin-4
- MeSH: Asthma*; Bronchitis, Chronic; Cytokines*; Humans; Interferon-gamma; Interleukin-10; Interleukin-2; Interleukin-4; Interleukin-5; Lymphotoxin-alpha; Male; T-Lymphocyte Subsets; T-Lymphocytes; Th1 Cells; Th2 Cells
- From:Tuberculosis and Respiratory Diseases 1998;45(1):90-98
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND: The CD4+ T-helper cells comprise functionally distinct subsets of Th1 and Th2 cells that are distinguished on the basis of differential cytokines production. Th1 cells secrete interferon-gamma, lymphotoxin, interleukin-2. Th2 cells produce interleukin-4, interleukin-5, interleukin-10. A previous study shown that Th2 cells and their cytokines increased in patients with atopic asthma. We compared cytokines(IL-4, IFN-gamma) activity and subpopulation of T-lymphocytes in peripheral blood from atopic asthmatics versus non-asthmatics. METHOD: Fifteen patients with atopic asthma(nine men, six women), twelve patients with chronic bronchitis (six men, six women), five healthy persons(three men, two women) were studied. Activity of IL-4, IFN-gamma and T-cell subpopulation in peripheral blood were estimated. RESULTS: Patients had a median age of 55yr. The mean activity of IL-4 of asthmatics was significantly increased(control 0.75+/-1.1pmol/L, atopic asthmatics 3.50+/-0.75pmol/L, chronic bronchitis 2.01+/-1.2pmol/L), but IFN- was not significantly increased. In the T lymphocyte subsets the percent of CD62L+ T-lymphocytes of asthmatics was not significantly increased(control 16.7+/-16.4 %, atopic asthmatics 24.8+/-23.6 %, chronic bronchitis 17.0+/-16.9%). CONCLUSION: In this study elevated production of IL-4 was observed in atopic asthmatics. CD62L+ T-lymphocytes was not increased in atopic asthma.
