Cytokines in Chronic Hepatitis B and C Virus Infections.
- Author:
Soon Ho KIM
1
Author Information
1. Department of Clinical Pathology, School of Medicine, Pusan National University Hospital, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Hepatitis B virus;
Hepatitis C virus;
Th1 cytokine;
Th2 cytokine
- MeSH:
Cytokines*;
Hepacivirus;
Hepatitis B virus;
Hepatitis B, Chronic*;
Hepatitis C;
Hepatitis C, Chronic;
Hepatitis, Chronic*;
Humans;
Liver;
T-Lymphocytes
- From:Korean Journal of Clinical Pathology
2001;21(1):6-12
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The cytokine patterns secreted by T cells at the site of viral replication may influence the final outcome of HBV and HCV infection. The different cytokine profiles of T cells within the liver in chronic HBV (Th0/Th2 cytokine) and HCV (Th1 cytokine) infections illustrate a different behavior of the local immune response in these two infections. The predominance of Th1-type cytokine responses has been reported to play an important role in viral clearance of patients with both acute and chronic hepatitis B. In contrast, a combined Th1-and Th2-like responses were found in chronic hepatitis C, exhibiting a pattern like that of acute hepatitis C with chronic evolution. It suggests that different patterns of cytokine expressions between HBV and HCV infection involve the difference in chronicity in each infection.
