A Matched Case-Control Study of a Novel Acid-Pump Antagonist and Proton-Pump Inhibitor for the Treatment of Iatrogenic Ulcers Caused by Endoscopic Submucosal Dissection.
- Author:
Yong Gil KIM
1
;
Byung Ik JANG
;
Tae Nyeun KIM
Author Information
1. Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. jbi@med.yu.ac.kr
- Publication Type:Original Article
- Keywords:
Revaprazan;
Rabeprazole;
Proton pump inhibitors;
Acid pump antagonists;
Endoscopic submucosal dissection
- MeSH:
2-Pyridinylmethylsulfinylbenzimidazoles;
Adenocarcinoma;
Case-Control Studies;
Glycosaminoglycans;
Humans;
Medical Records;
Middle Aged;
Mucous Membrane;
Proton Pump Inhibitors;
Pyrimidinones;
Regeneration;
Stomach Neoplasms;
Tetrahydroisoquinolines;
Ulcer
- From:Gut and Liver
2010;4(1):25-30
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Revaprazan, a novel acid-pump antagonist, and proton-pump inhibitors (PPIs) have pH-independent effects on ulcer healing. The addition of a PPI promotes the cell restitution rate as well as vessel regeneration and maturation for ulcer repair. Revaprazan is known to protect the mucosa by increasing the prostaglandin concentration. METHODS: We reviewed the medical records of patients who underwent endoscopic submucosal dissection (ESD) for gastric neoplasia at Yeungnam University Hospital between January 2008 and May 2009. We conducted a matched case-control study to compare the healing rates effected by revaprazan and rabeprazole. RESULTS: Each group consisted of 30 patients. The baseline characteristics did not differ significantly between the two groups. Stage S1 disease was observed in 97% and 100% of patients after 8 weeks of treatment in the revaprazan and rabeprazole groups, respectively. In the revaprazan group, only one patient had stage H2 disease: a 54-year-old man with a 5.5-cm lesion after ESD of the ulcer, type IIa early gastric cancer, and adenocarcinoma. No serious adverse effects occurred during the treatment period in either group. CONCLUSIONS: The safety and efficacy profiles of revaprazan and rabeprazole are similar for the treatment of ESD-induced ulcers.
