Acute Hemorrhagic Colitis Induced by Oral Administration of Oseltamivir.
10.12771/emj.2016.39.2.56
- Author:
Hyun Soo KIM
1
;
Min Wook KIM
;
Si Ho KIM
;
Geun KIM
;
Jung Hyun LEE
Author Information
1. Department of Internal Medicine, Hongik Hospital, Seoul, Korea. drprin@naver.com
- Publication Type:Case Report
- Keywords:
Oseltamivir;
Hemorrhagic colitis;
Influenza
- MeSH:
Abdominal Pain;
Administration, Oral*;
Adolescent;
Colitis*;
Colitis, Ischemic;
Colon, Descending;
Diarrhea;
Edema;
Estrogens, Conjugated (USP);
Gastrointestinal Hemorrhage;
Humans;
Hyalin;
Influenza, Human;
Ischemia;
Korea;
Male;
Mucous Membrane;
Nausea;
Oseltamivir*;
Risk Factors;
Vomiting
- From:The Ewha Medical Journal
2016;39(2):56-60
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Oseltamivir has been used as a worldwide preparation for treatment of influenza A and B including H1N1. Gastrointestinal discomforts as like nausea, vomiting are commonly reported but acute hemorrhagic colitis is a very rare adverse effect. We report a case of a 17-year-old male who showed abdominal pain, diarrhea and hematochezia after the second administration of oseltamivir. Computed tomography revealed continuous, circumferential and edematous wall thickening involving ascending to descending colon with pericolic infiltration. Colonoscopic examination revealed diffuse mucosal edema, congestion and friability, suggesting hemorrhagic colitis. Histopathological examination showed ischemia and focal loss of the crypts. It also showed hyalinization and minimal inflammatory cell infiltration in the lamina propria, consistent with acute to subacute ischemic colitis. This report is the first case of oseltamivir-related ischemic colitis proved by both endoscopic examination and pathologic findings in the patient who had no risk factor of ischemic colitis in Korea.
