Methylene Blue Solution-induced Acute Esophageal Mucosal Injury: First Case Report.
- Author:
Ock Bae KO
1
;
Do Hoon KIM
;
Jung Min KANG
;
Hwoon Young JUNG
Author Information
1. Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. kdh0358@hanmail.net
- Publication Type:Case Report
- Keywords:
Methylene blue;
Esophagus;
Injury
- MeSH:
Adenocarcinoma;
Aged;
Anastomotic Leak;
Endoscopy, Digestive System;
Esophagus;
Humans;
Jaundice;
Klatskin's Tumor;
Metaplasia;
Methylene Blue;
Mucous Membrane;
Weight Loss
- From:Korean Journal of Gastrointestinal Endoscopy
2011;42(3):161-164
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Methylene blue (MB) based chromoendoscopy has been used for more than a decade to increase detection rates of specialized intestinal metaplasia, dysplasia, and esophageal adenocarcinoma. It is also used to detect anastomotic leakage after an operation. A 67-year-old man with no previous medical problems had complaints of jaundice and weight loss for 2 months. He was diagnosed with a Klatskin tumor and was referred to our hospital. An initial esophagogastroduodenoscopy (EGD) was performed before the operation. No abnormality was observed in the esophagus. MB solution was infused via an L-tube to check for leakage in the anastomosis. Subepithelial hemorrhagic and edematous mucosal changes with friability and a bluish mucosal discoloration were noted 2 days later from the mid to lower esophagus on EGD. Nine months later, an EGD revealed an unremarkable esophageal mucosa. MB solution is considered safe; however, a large volume or high concentration of MB solution might be harmful.
