Investigation on some pharmacological effects of the product magaldrate (malumix) in the treatment of gastric duodenal ulcer
- Author:
Quang Minh Do
- Publication Type:Journal Article
- Keywords:
Gastroduodenal ulcer
- MeSH:
Peptic Ulcer;
Therapeutics;
Magaldrate;
Pharmaceutical Preparations
- From:Pharmaceutical Journal
1999;282(10):20-23
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Magaldrate (malumix) is a chemical combination of magnesium and aluminum hydroxides used an antacid. It has a rapid action, high acid consuming capacity. Studies in vitro showed that magaldrate (malumix) possessed some antipepsin activity. At pH = 1.5 proteolysis was inhibited 55% by malumix. Pretreatment with Malumix suspension 30 minutes before ethanol reduced the severity and extent of gastric mucosal lesions at dose-dependent manner. Magaldrate (malumix) had not acute toxicity in vivo test.
