Catheter-directed Thrombolysis of Below-Knee Deep Venous Thrombosis of the Lower Extremities.
10.3348/jkrs.2008.58.2.121
- Author:
Byung Suk ROH
1
;
Young Jun SOHN
;
Eun A HEO
;
Hyun Sun CHO
;
Seong Hoon PARK
;
Young Hwan LEE
Author Information
1. Department of Radiology, Wonkwang University Hospital, Korea. bsroh@wonkwang.ac.kr
- Publication Type:Clinical Trial ; Original Article
- Keywords:
Venous thrombosis;
Thrombolytic therapy;
Lower extremity
- MeSH:
Constriction, Pathologic;
Female;
Humans;
Lower Extremity;
Male;
Phlebography;
Popliteal Vein;
Prospective Studies;
Thrombolytic Therapy;
Thrombosis;
Urokinase-Type Plasminogen Activator;
Veins;
Venous Thrombosis
- From:Journal of the Korean Radiological Society
2008;58(2):121-125
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the technical feasibility and clinical efficacy of the use of local thrombolysis for below-knee deep vein thrombosis (DVT). MATERIALS AND METHODS: From a population of 41 patients with a lower extremity DVT, the prospective clinical trial included 11 patients (7 female, 4 male, average age 61.4 years) treated with catheter-directed thrombolysis with urokinase for below-knee DVT. After removal of the proximal ilofemoral DVT, additional interventional procedures to remove the residual thrombus and restore the venous flow from the below-knee vein were performed in cases of continuous occlusion of venous flow from the popliteal and tibial veins. Under ultrasound (US) guidance, catheter-directed thrombolysis with urokinase was performed through the ipsilateral popliteal vein. After administration of oral anticoagulation therapy, CT and venography were performed to identify patency and the presence of a recurrent thrombosis. RESULTS: Successful removal of the thrombus and restoration of venous flow were achieved in all of the patients (100%). Restoration of flow with a residual thrombus occurred in one case. Focal venous stenosis was discovered in four cases. The duration of urokinase infusion was 1-4 days (average 2.36 days), which was considered long. For 15.2 months, the venous lumen of all cases was preserved without a recurrent thrombosis. CONCLUSION: Catheter-directed thrombolysis is an effective procedure for recanalization of below-knee DVT in patients with a lower extremity DVT.
