Clinical significance of microvessel density in multiple myeloma patients.
10.3346/jkms.2001.16.1.45
- Author:
Myung Ju AHN
1
;
Chan Kum PARK
;
Jung Hye CHOI
;
Won Mee LEE
;
Young Yeul LEE
;
Il Young CHOI
;
In Soon KIM
;
Woong Soo LEE
;
Moran KI
Author Information
1. Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. ahnmj@email.hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Microvessel Density;
Multiple Myeloma;
Survival
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Bone Marrow/blood supply;
Endothelial Growth Factors/physiology;
Female;
Hematopoietic Stem Cell Transplantation;
Human;
Lymphokines/physiology;
Male;
Microcirculation;
Middle Age;
Multiple Myeloma/therapy;
Multiple Myeloma/mortality;
Multiple Myeloma/blood supply*;
Neovascularization, Pathologic/physiopathology*;
Survival Rate
- From:Journal of Korean Medical Science
2001;16(1):45-50
- CountryRepublic of Korea
- Language:English
-
Abstract:
To investigate the role of angiogenesis in multiple myeloma (MM), bone marrow biopsy from 75 adults with newly diagnosed, untreated MM were evaluated. Microvessels were scored in at least 3 areas ( x 200 fields) of the highest microvessel density in representative sections of each bone marrow specimen using immunohistochemistry for CD34. Prognostic variables were also evaluated for the overall survival. Microvessel counts were significantly higher in patients with MM (n=69.42+/-9.67), compared with control (n=26.81+/-2.85). Microvessel density had a weak correlation with percentage of bone marrow plasma cells. By univariate analysis, age, beta2-microglobulin, serum albumin, serum creatinine, serum calcium, hemoglobin, platelet count, and bone marrow plasma cell percentage were correlated with survival. By multivariate analysis, age, serum albumin, serum creatinine, hemoglobin, platelet count and bone marrow plasma cell percentage were correlated with overall survival, whereas microvessel density was not. In summary, microvessel density in bone marrow of MM is significantly increased compared to control, but was not correlated with overall survival. Further studies regarding angiogeneic molecules are needed to determine the functional role of angiogenesis in MM.
