Correlation of VEGF with contrast enhancement on dual-phase dynamic helical CT in liver tumors: preliminary study.
10.3346/jkms.2001.16.1.83
- Author:
Byung Kook KWAK
1
;
Hyung Jin SHIM
;
Un Sub PARK
;
Tae Jin LEE
;
Sung Suk PAENG
;
Chang Jun LEE
;
Hyo K LIM
;
Cheol Keun PARK
Author Information
1. Department of Radiology, Chung-Ang University College of Medicine, Seoul, Korea. kbk6824@chollian.net
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Vascular Endothelial Growth Factor (VEGF);
Computed Tomography, Contrast Enhancement;
Liver;
Liver Neoplasms;
Liver Neoplasms, Blood Supply;
Computed Tomography, Helical
- MeSH:
Adult;
Aged;
Capillary Permeability;
Endothelial Growth Factors/physiology*;
Endothelial Growth Factors/analysis;
Female;
Human;
Liver Neoplasms/radiography*;
Liver Neoplasms/blood supply;
Lymphokines/physiology*;
Lymphokines/analysis;
Male;
Middle Age;
Prospective Studies;
Radiographic Image Enhancement*;
Tomography, X-Ray Computed
- From:Journal of Korean Medical Science
2001;16(1):83-87
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this preliminary study is to elucidate that vascular endothelial growth factor (VEGF) influences contrast enhancement of hepatic tumors on computed tomography (CT). Fourteen patients with hepatic tumors (11 hepatocellular carcinomas; 3 metastatic cancers) underwent a dual-phase dynamic helical CT or computed tomographic hepatic arteriography. The attenuation of each mass was determined as hyperattenuation, isoattenuation or hypoattenuation with respect to the adjacent nontumorous parenchyma. Gun-needle biopsy was done for each tumor, and paraffin sections were immunostained with anti- VEGF antibody by the avidin-biotin-peroxidase complex method. The pathologic grade was made by intensity (1 +, 2+, 3+) and area (+/-, 1 +, 2+). The tumor ranged 2.0-14.0 cm in size (mean, 5.8 cm). In arterial phase, the intensity was not correlated with the degree of enhancement (p=0.086). However, the correlation between the attenuation value of hepatic arterial phase and the area of positive tumor cells was statistically significant (p=0.002). VEGF may be the factor that enhances the hepatic mass with water-soluble iodinated contrast agent in CT.
