Serum high sensitivity C-reactive protein levels in obese middle school boys.
10.3345/kjp.2006.49.6.617
- Author:
Jae Ho JEONG
1
;
Jae Woo LIM
;
Eun Jeong CHEON
;
Kyong Og KO
;
Young Hyuk LEE
Author Information
1. Department of Pediatrics, College of Medicine, Konyang University, Daejeon, Korea. kcm1000@kyuh.co.kr
- Publication Type:Original Article
- Keywords:
Obesity;
hs-CRP;
Metabolic syndrome
- MeSH:
Apolipoproteins;
Blood Pressure;
C-Reactive Protein*;
Child;
Dyslipidemias;
Humans;
Immunoassay;
Inflammation;
Latex;
Myocardial Infarction;
Obesity;
Triglycerides
- From:Korean Journal of Pediatrics
2006;49(6):617-622
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: High-Sensitivity C-reactive protein(hs-CRP) has been recognized as a very useful and sensitive predictor of the future risk of myocardial infarction. But the clinical significance of hs-CRP in children remains uncertain. To confirm the existence of obesity-induced vascular inflammation and the association between metabolic syndromes and elevation of CRP in children, we investigated the relationship among CRP, obesity, blood pressure(BP), and serum lipids in schoolboys. METHODS: Twenty-eight obese(BMI 29.61+/-3.29 kg/m2) and 93 non-obese(BMI 18.99+/-2.21 kg/m2) boys aged 14 years were examined. Serum CRP levels was measured by the high sensitive latex turbidimetric immunoassay and subjects with CRP levels below 0.3 mg/dL were adopted to avoid the influence of acute infection. RESULTS: Obese children had significantly higher hs-CRP levels than their non-obese group(0.104+/-0.075 vs. 0.054+/-0.005 mg/dL). In the obese group, BMI, systolic blood pressure, diastolic blood pressure, apolipoprotein B, atherogenic index, and triglyceride were significantly higher than in non-obese. The BMI, diastolic blood pressure, apolipoprotein E, atherognic index, and triglyceride showed positive correlation with log CRP by simple regression. Multiple regression analysis indicated that BMI and apolipoprotein E were strongly related to CRP. CONCLUSION: This study revealed that obese children tended to have higher levels of serum hs-CRP, BP elevation and dyslipidemia than the control group and that BMI and apolipoprotein E were strongly related to CRP. These results indicate that obesity related metabolic syndrome can be developed in children.
