A study of the current(2003-2005) prevalence of anti-HBs and immunologic memory of hepatitis B vaccine in children from the central area of Korea.
10.3345/kjp.2006.49.6.630
- Author:
Young Won AN
1
;
Eun Hee CHUNG
;
Insoo RHEEM
Author Information
1. Department of Pediatrics, College of Medicine, Dankook University, Cheonan, Korea. ehchung@dankook.ac.kr
- Publication Type:Original Article
- Keywords:
Hepatitis B vaccine;
Booster vaccination;
Immunologic memory
- MeSH:
Adolescent;
Antibodies;
Child*;
Hepatitis B Surface Antigens;
Hepatitis B Vaccines*;
Hepatitis B*;
Hepatitis*;
Humans;
Immunoglobulin G;
Immunologic Memory*;
Korea*;
Prevalence*;
Vaccination
- From:Korean Journal of Pediatrics
2006;49(6):630-634
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was conducted to assess the current(2003-2005) prevalence of anti-HBs and immunologic memory for Hepatitis B vaccine in children from the central area of Korea. METHODS: Subjects were chosen from children and adolescents who received tests for hepatitis B surface antigen(HBsAg) and anti-HBs at Dankook University Hospital from March 2003 to May 2005. Among these, antibodies to hepatitis B core antigen(IgG anti-HBc) were checked. A single booster vaccination was performed on children whose anti-HBs titers were under 10 mIU/mL. One month after booster vaccination we rechecked the anti-HBs titer. RESULTS: A total of 3,277 subjects were tested for HBsAg/anti-HBs, and 1,913(58.4 percent) of them were positive for anti-HBs. Of these, 29 subjects(0.9 percent) were positive for HBsAg. Positive results for anti-HBs by age were 78.6 percent for 6-12 months of age, 62.7 percent for 1-3 years of age, 51.9 percent for 4-6 years of age, 49.5 percent for 7-12 years of age, 63.4 percent for 13-15 years of age and 72.2 percent for 16-18 years of age. The 80 subjects who were tested negative for HBsAg/anti-HBs received a single booster vaccine, 71 subjects were tested positive for antibodies. IgG anti-HBc titer was checked for 169 of the subjects, 5 subjects were positive. CONCLUSION: In our study, a significant anamnestic response was observed in 88.8 percent of children. This is believed to be a result of the relatively long immunologic memory effect of the hepatitis B vaccination in children from the central area of Korea.
