Blood Level of Soluble CD30 and Soluble E-Selectin in Allergic Rhinitis Patients.
- Author:
Kyoung Ho JUN
1
;
Ha Min JEONG
;
Sang Heon CHOI
;
Jae Hoon LEE
Author Information
1. Department of Otolaryngology-Head & Neck Surgery, Institute of Wonkwang Medical Science, School of Medicine, Wonkwang University, Iksan, Korea. nose-1023@hanmail.net
- Publication Type:Original Article
- Keywords:
Allergic rhinitis;
CD30;
E-selectin
- MeSH:
Asthma;
Cytokines;
Dermatitis, Atopic;
E-Selectin;
Humans;
Rhinitis;
Rhinitis, Allergic, Perennial
- From:Journal of Rhinology
2011;18(2):112-115
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Blood levels of soluble CD30 and soluble E-selectin are related to allergic diseases such as atopic dermatitis or asthma. However, these levels have not been well investigated in allergic rhinitis. We evaluated the association of blood concentrations of these cytokines in allergic rhinitis. MATERIALS AND METHODS: The concentrations of soluble CD30 and soluble E-selectin in blood were analyzed by enzyme linked immunosorbant assay. The levels of these cytokines were compared between allergic rhinitis patients (n=48) and age-matched healthy controls (n=27), and a relationship was found with symptom severity. RESULT: The concentration of soluble CD30 was significantly increased in allergic rhinitis patients compared to that in normal healthy people (p=0.042). However, soluble E-selectin was not significantly increased in allergic rhinitis patients (p>0.05). CONCLUSION: These results suggest a possible role of soluble CD30 in the blood of allergic rhinitis.
