Arterial Stiffness is Associated With Diabetic Retinopathy in Korean Type 2 Diabetic Patients.
10.3961/jpmph.2011.44.6.260
- Author:
Yong Woon YUN
1
;
Min Ho SHIN
;
Young Hoon LEE
;
Jung Ae RHEE
;
Jin Su CHOI
Author Information
1. Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea. mhshinx@paran.com
- Publication Type:Original Article
- Keywords:
Carotid plaque;
Diabetes mellitus;
Diabetic retinopathy;
Intima-media thickness;
Peripheral arterial disease;
Pulse wave velocity
- MeSH:
Aged;
Aged, 80 and over;
Ankle Brachial Index;
Carotid Artery Diseases/epidemiology/*pathology;
Confidence Intervals;
Diabetes Mellitus, Type 2/epidemiology/*pathology;
Diabetic Retinopathy/epidemiology/*pathology;
Female;
Humans;
Logistic Models;
Male;
Odds Ratio;
Peripheral Arterial Disease/epidemiology/*pathology;
Republic of Korea/epidemiology;
Risk Assessment;
Tunica Intima/pathology;
Tunica Media/pathology
- From:Journal of Preventive Medicine and Public Health
2011;44(6):260-266
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: We evaluated the association between common carotid artery intima-media thickness (CCA-IMT), brachial-ankle pulse wave velocity (baPWV), carotid plaque, and peripheral arterial disease (PAD) as indicators of macroangiopathy and diabetic retinopathy as an indicator of microangiopathy in type 2 diabetic patients. METHODS: We analyzed 605 type 2 diabetic patients registered at a public health center in Korea. Following overnight fasting, venous blood and urine samples were collected and analyzed. The CCA-IMT, levels of carotid plaque, baPWV, and ankle-brachial index (ABI) of the subjects were assessed. We used non-mydriatic fundus photography to diagnose diabetic retinopathy. Multiple logistic regression analyses were used to evaluate the association between macroangiopathy and diabetic retinopathy. CCA-IMT and baPWV were divided into tertiles: CCA-IMT, 0.39 to 0.65 mm, 0.66 to 0.78 mm, and 0.79 to 1.30 mm; baPWV, 9.9 to 15.8 m/s, 15.9 to 18.9 m/s, and 19.0 to 38.0 m/s. RESULTS: The association between baPWV and diabetic retinopathy remained significant after adjustment, with an increasing odds ratio (OR) in the second tertile (OR, 2.41; 95% confidence interval [CI], 1.27 to 4.55) and the third tertile (OR, 4.63; 95% CI, 2.33 to 9.21). No significant differences were observed in carotid plaque, PAD, and each tertile of CCA-IMT. CONCLUSIONS: BaPWV was associated with diabetic retinopathy, while CCA-IMT, carotid plaque, and PAD were not. This study suggests that the association between macroangiopathy and microangiopathy may be attributable to functional processes rather than structural processes within the vascular system.
