Glutathione S-Transferase M1 Polymorphism and Schizophrenia.
- Author:
Chi Un PAE
1
;
Ja Hyun JO
;
Yeon Joo KIM
;
Tae Suk KIM
;
Jung Jin KIM
;
Chang Uk LEE
;
Soo Jung LEE
;
Tae Youn JUN
;
Chul LEE
;
In Ho PAIK
Author Information
1. Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea. knpsy@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
GSTM1 gene polymorphism;
Schizophrenia;
Tardive dyskinesia
- MeSH:
Dyskinesias;
Genotype;
Glutathione Transferase*;
Glutathione*;
Humans;
Inpatients;
Movement Disorders;
Schizophrenia*
- From:Journal of Korean Neuropsychiatric Association
2004;43(5):519-523
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study aimed to test the possible association between Glutathione S-Transferase M1 gene (GSTM1) variants and schizophrenia. METHODS: One hundred and eleven inpatients with schizophrenia and 130 healthy controls were recruited. Genotyping was performed by polymerase chain reaction-based method. RESULTS: The GSTM1 null genotype was significantly more frequent in patients with schizophrenia than in controls (p=0.014, odd ratio=1.93, 95% confidence interval=1.115-3.351), while GSTM1 genotype variants were not associated with either tardive dyskinesia (TD) or total Abnormal Involuntary Movement Scale (AIMS) scores. CONCLUSION: The present study suggests that the GSTM1 polymorphism may confer susceptibility to the development of schizophrenia but not to TD, at least in Korean population.
