A Study on Depression, Anxiety and Quality of Life in Amenorrhea Schizophrenics Treated with Risperidone.
- Author:
Youn Hee KIM
1
;
Kyu Wol YUN
;
Mi Kyung KIM
;
Hye Jean LEE
Author Information
1. Seoul National Hospital, Seoul, Korea. 3plus7@hanmail.net
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Risperidone;
Hyperprolactinemia;
Depression;
Anxiety;
Quality of life
- MeSH:
Amenorrhea*;
Antipsychotic Agents;
Anxiety*;
Depression*;
Female;
Galactorrhea;
Hostility;
Humans;
Hyperprolactinemia;
Mental Health;
Pregnancy;
Prolactin;
Quality of Life*;
Risperidone*;
Schizophrenia
- From:Journal of Korean Neuropsychiatric Association
2004;43(5):537-545
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Amenorrhea, one of the most common side effects of neuroleptics, has known to be associated with prolactin elevation. Hyperprolactinemia seriously affects mental health causing depression, anxiety or hostility, while also affecting physical health causing amenorrhea, galactorrhea or sexual dysfunction. The possible correlation between risperidone-induced amenorrhea and depression, anxiety and quality of life was evaluated in a cross-sectional open study. METHODS: During a five-month period, WHO quality of life-BREF (WHOQOL), Beck depression inventory (BDI) and Statetrait anxiety inventory (STAI) were applied twice at two-month intervals for 30 patients with risperidone-induced amenorrhea and 22 patients without amenorrhea. RESULTS: Amenorrhea group had significantly higher scores in BDI and STAI-state, while showing lower scores in the quality of life than control group. The total BDI and STAI-state scores were more negatively correlated with WHOQOL score in amenorrhea group. CONCLUSION: Patients with risperidone-induced amenorrhea rated themselves significantly more depressed and more anxious, and a lower quality of life compared to the control group. Clinicians should be more active in evaluating and treating hyperprolactinemic side effects such as amenorrhea, galactorrhea, depression and anxiety.
