Fluoxetine as a Treatment for Premature Ejaculation: A Double-Blind, Randomized, Placebo-Controlled Study.
- Author:
Tai Young AHN
1
;
Hyungkeun PARK
;
Eun Ho CHOI
;
Myung Soo CHOO
;
Taehan PARK
Author Information
1. Department of Urology, Asan Medical Center, Seoul, Korea.
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
ejaculation;
serotonin;
fluoxetine;
medication
- MeSH:
Ejaculation;
Fatigue;
Female;
Fluoxetine*;
Humans;
Male;
Outpatients;
Premature Ejaculation*;
Serotonin;
Yawning
- From:Korean Journal of Urology
1996;37(8):926-931
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Premature ejaculation is the most common male sexual dysfunction and defined as persistent or recurrent occurrences of ejaculation before or shortly after penetration. But there has never been any effective oral agents for the patients with premature ejaculation. Recently, fluoxetine, a potent serotonin reuptake inhibitor, being used as antidepressant, has been suggested to be helpful for the patients with premature ejaculation. Twenty three male outpatients with premature ejaculation were randomly divided into fluoxetine (n=12) and placebo (n=11) group. In the fluoxetine group, the dose of fluoxetine was 20 mg/day for the first one week and 40 mg/day for the remaining 5 weeks. Patient and his female partner were interviewed separately before starting medication, three weeks and six weeks after medication. The mean intravaginal ejaculation latency time increased to 187.5 seconds after 3 weeks and 254.2 seconds after 6 weeks front 46.7 seconds before treatment (p<0.05). Only 1 out of 12 patients in the fluoxetine group was able to have thrusts over 30 times before treatment. After 3 weeks of Treatment, 8of 12 patients and after 6 weeks of treatment, 7 patients were able to have thrusts over 30 times. There was no significant improvement of intravaginal ejaculation latency time and number of thrusts in the placebo group. Symptomatic improvement was noticed in 75% with fluoxetine group and 18.2% with placebo group. Side reactions of fluoxetine, fatigue and yawning, were noticed in 41% of the patients, but they did not interfere with their daily activities. These findings suggest that fluoxetine can be safely used as a good pharmacotherapeutic treatment for the patients with premature ejaculation.
