Study of the skin concentrations after administration of the various phototoxic drugs.
10.3349/ymj.1991.32.3.231
- Author:
Yoon Kee PARK
1
;
Seung Kyung HANN
;
Moo Yon CHO
;
Hyung Joo KIM
;
Sang Chul SHIM
;
Seung Ju CHOI
;
Mi Hong YUN
Author Information
1. Department of Dermatology, Yonsei University College of Medicine, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Skin concentration;
8-MOP;
5-MOP;
TMP
- MeSH:
Administration, Cutaneous;
Administration, Oral;
Animal;
Guinea Pigs;
Methoxsalen/administration & dosage/*analysis;
PUVA Therapy;
Skin/*chemistry;
Support, Non-U.S. Gov't;
Trioxsalen/administration & dosage/*analysis
- From:Yonsei Medical Journal
1991;32(3):231-236
- CountryRepublic of Korea
- Language:English
-
Abstract:
The skin concentrations of 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP), and 4, 5', 8-trimethylpsoralen (TMP) were studied in the guinea pig following oral administration and bathing. The skin concentration of phototoxic drugs after oral administration peaked at 1.5 hours, and the concentration of 8-MOP was 3.5 times greater than that of 5-MOP. The skin concentration of TMP was not detected in our study (limit of sensitivity 5ng/ml). The skin concentrations of phototoxic drug after bathing decreased in the order of 5-MOP, TMP, and 8-MOP
